Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review

AK Rajendran, D Sankar, S Amirthalingam… - Biomaterials …, 2023 - Springer
Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

H Zhou, M Wang, Y Zhang, Q Su, Z **e… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

BL Doss, M Pan, M Gupta, G Grenci, RM Mège… - Proceedings of the …, 2020 - pnas.org
Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …

Mechanobiology of tumor growth

PK Chaudhuri, BC Low, CT Lim - Chemical reviews, 2018 - ACS Publications
Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

[HTML][HTML] A primer to traction force microscopy

A Zancla, P Mozetic, M Orsini, G Forte… - Journal of Biological …, 2022 - Elsevier
Traction force microscopy (TFM) has emerged as a versatile technique for the measurement
of single-cell-generated forces. TFM has gained wide use among mechanobiology …

Hydrodynamics in cell studies

D Huber, A Oskooei, X Casadevall i Solvas… - Chemical …, 2018 - ACS Publications
Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

Nanoparticle–cell interaction: a cell mechanics perspective

D Septiadi, F Crippa, TL Moore… - Advanced …, 2018 - Wiley Online Library
Progress in the field of nanoparticles has enabled the rapid development of multiple
products and technologies; however, some nanoparticles can pose both a threat to the …

Cell shape and forces in elastic and structured environments: from single cells to organoids

R Link, K Weißenbruch, M Tanaka… - Advanced Functional …, 2024 - Wiley Online Library
With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …

Measurement of cell traction forces with ImageJ

JL Martiel, A Leal, L Kurzawa, M Balland, I Wang… - Methods in cell …, 2015 - Elsevier
The quantification of cell traction forces requires three key steps: cell plating on a
deformable substrate, measurement of substrate deformation, and the numerical estimation …

Biomechanical characterization at the cell scale: present and prospects

F Basoli, SM Giannitelli, M Gori, P Mozetic… - Frontiers in …, 2018 - frontiersin.org
The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …