Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of
pathological processes including tissue inflammation and tumor dissemination but is …

The blood and lymphatic systems are the two major circulatory systems in our body.
Although the blood system has been studied extensively, the lymphatic system has received …

The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Historically, primary lymphoedema was classified into just three categories depending on
the age of onset of swelling; congenital, praecox and tarda. Developments in clinical …

Primary lymphatic anomalies may present in a myriad of ways and are highly heterogenous.
Careful consideration of the presentation can lead to an accurate clinical and/or molecular …

Rationale: Mutations in vascular endothelial growth factor (VEGF) receptor-3 (VEGFR3 or
FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital …

The lymphatic and blood vascular systems function in concert to regulate the tissue fluid
homeostasis of the body. The pum** force of the heart generates a hydrostatic pressure …

Background: Lymphedema results from maldevelopment of the lymphatic system (primary)
or injury to lymphatic vasculature (secondary). Primary lymphedema is far less common than …

Rationale: Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively,
are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient …