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Biosynthesis of fungal terpenoids
Covering: up to August 2023 Terpenoids, which are widely distributed in animals, plants,
and microorganisms, are a large group of natural products with diverse structures and …
and microorganisms, are a large group of natural products with diverse structures and …
The expanded CRISPR toolbox for constructing microbial cell factories
Microbial cell factories (MCFs) convert low-cost carbon sources into valuable compounds.
The CRISPR/Cas9 system has revolutionized MCF construction as a remarkable genome …
The CRISPR/Cas9 system has revolutionized MCF construction as a remarkable genome …
Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi
Terpenoids, critical components of human medicine, are the largest family of natural
products. Fungi are an important source of terpenoids, but many of the corresponding …
products. Fungi are an important source of terpenoids, but many of the corresponding …
[HTML][HTML] Strategies to establish the link between biosynthetic gene clusters and secondary metabolites
Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of
which have found applications in the pharmaceutical industry including as antibiotics and …
which have found applications in the pharmaceutical industry including as antibiotics and …
Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage
Enfumafungin-type antibiotics, represented by enfumafungin and fuscoatroside, belong to a
distinct group of triterpenoids derived from fungi. These compounds exhibit significant …
distinct group of triterpenoids derived from fungi. These compounds exhibit significant …
Secondary metabolite biosynthetic diversity in the fungal family Hypoxylaceae and Xylaria hypoxylon
To date little is known about the genetic background that drives the production and
diversification of secondary metabolites in the Hypoxylaceae. With the recent availability of …
diversification of secondary metabolites in the Hypoxylaceae. With the recent availability of …
Total synthesis of viridin and viridiol
Y Ji, Z **n, H He, S Gao - Journal of the American Chemical …, 2019 - ACS Publications
The asymmetric total synthesis of (−)-viridin and (−)-viridiol, antifungal metabolites, was
achieved in 17 and 18 steps from a commercially available starting material. An …
achieved in 17 and 18 steps from a commercially available starting material. An …
Anticancer fungal natural products: Mechanisms of action and biosynthesis
Many fungal metabolites show promising anticancer properties both in vitro and in animal
models, and some synthetic analogs of those metabolites have progressed into clinical …
models, and some synthetic analogs of those metabolites have progressed into clinical …
Fungal dirigent protein controls the stereoselectivity of multicopper oxidase-catalyzed phenol coupling in viriditoxin biosynthesis
Paecilomyces variotii produces the antibacterial and cytotoxic (M)-viriditoxin (1) together
with a trace amount of its atropisomer (P)-viriditoxin 1′. Elucidation of the biosynthesis by …
with a trace amount of its atropisomer (P)-viriditoxin 1′. Elucidation of the biosynthesis by …
Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts
H Oikawa - Bioscience, Biotechnology, and Biochemistry, 2020 - academic.oup.com
Ascomycota and basidiomycota fungi are prolific sources of biologically active natural
products. Recent genomic data and bioinformatic analysis indicate that fungi possess a …
products. Recent genomic data and bioinformatic analysis indicate that fungi possess a …