Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery

C Qiu, F **a, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …

Transmission electron microscopy as a powerful tool to investigate the interaction of nanoparticles with subcellular structures

M Malatesta - International journal of molecular sciences, 2021 - mdpi.com
Nanomedical research necessarily involves the study of the interactions between
nanoparticulates and the biological environment. Transmission electron microscopy has …

Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity

G Liu, M Zhu, X Zhao, G Nie - Advanced drug delivery reviews, 2021 - Elsevier
After centuries of development, using vaccination to stimulate immunity has become an
effective method for prevention and treatment of a variety of diseases including infective …

Tracking the endosomal escape: A closer look at calcein and related reporters

F Hausig‐Punke, F Richter, M Hoernke… - Macromolecular …, 2022 - Wiley Online Library
Crossing the cellular membrane and delivering active pharmaceuticals or biologicals into
the cytosol of cells is an essential step in the development of nanomedicines. One of the …

Nanoparticle mediated RNA delivery for wound healing

E Kolanthai, Y Fu, U Kumar, B Babu… - Wiley …, 2022 - Wiley Online Library
Wound healing is a complicated physiological process that comprises various steps,
including hemostasis, inflammation, proliferation, and remodeling. The wound healing …

Biodegradable gold nanoclusters with improved excretion due to pH-triggered hydrophobic-to-hydrophilic transition

EM Higbee-Dempsey, A Amirshaghaghi… - Journal of the …, 2020 - ACS Publications
Gold is a highly useful nanomaterial for many clinical applications, but its poor
biodegradability can impair long-term physiological clearance. Large gold nanoparticles (∼ …

Self-modifying NanoEnhancers facilitating lysosomal escape for cGAS-STING cascading activation in tumor immunotherapy

Y Ge, Y Bao, A Shao, K **, Z Mao, W Tong, J Ye - Nano Today, 2024 - Elsevier
Targeting mitochondria has emerged as an effective approach in recent tumor
immunotherapy. While nanosized carriers have been utilized for therapeutic drug delivery …

Non-viral carriers for nucleic acids delivery: Fundamentals and current applications

S Shtykalova, D Deviatkin, S Freund, A Egorova… - Life, 2023 - mdpi.com
Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles

AM Butt, N Abdullah, NNIM Rani, N Ahmad… - Pharmaceutical …, 2022 - Springer
Cytoplasmic delivery of bioactives requires the use of strategies such as active transport,
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …

Nano‐Biointeractions of Functional Nanomaterials: The Emerging Role of Inter‐Organelle Contact Sites, Targeting, and Signaling

N Blal, G Bardi, PP Pompa… - Advanced Functional …, 2024 - Wiley Online Library
The study of nano‐biointeractions, at the forefront of interdisciplinary research, unveils
intricate interplays between nanomaterials (NMs) and intracellular organelles, which are …