Review of the endocannabinoid system

HC Lu, K Mackie - Biological Psychiatry: Cognitive Neuroscience and …, 2021 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the develo** central nervous system as well as playing a major role in tuning many …

An introduction to the endogenous cannabinoid system

HC Lu, K Mackie - Biological psychiatry, 2016 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

[HTML][HTML] Endocannabinoid-mediated control of synaptic transmission

M Kano, T Ohno-Shosaku… - Physiological …, 2009 - journals.physiology.org
The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

A Ciechanover, YT Kwon - Experimental & molecular medicine, 2015 - nature.com
Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies

DP Finn, S Haroutounian, AG Hohmann, E Krane… - Pain, 2021 - journals.lww.com
This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Multiple functions of endocannabinoid signaling in the brain

I Katona, TF Freund - Annual review of neuroscience, 2012 - annualreviews.org
Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

I Katona, TF Freund - Nature medicine, 2008 - nature.com
Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in
various therapeutic applications from pain to epilepsy, but its psychotropic effect has …

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

K Ahn, MK McKinney, BF Cravatt - Chemical reviews, 2008 - ACS Publications
Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice

Y Gao, DV Vasilyev, MB Goncalves… - Journal of …, 2010 - Soc Neuroscience
Endocannabinoids (eCBs) function as retrograde signaling molecules at synapses
throughout the brain, regulate axonal growth and guidance during development, and drive …

Endocannabinoid signaling and long-term synaptic plasticity

BD Heifets, PE Castillo - Annual review of physiology, 2009 - annualreviews.org
Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in …