Substantial improvements have been made in the management of metastatic colorectal
cancer over the last two decades. The overall survival of patients diagnosed with …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Colorectal cancer (CRC) is the third most common cancer worldwide, with 1.1 million new
cases per year, and is the second leading cause of cancer death. 1 CRC occurs more …

The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …

Colorectal cancer (CRC) is one of the most common malignancies in Western countries.
Over the last 20 years, and the last decade in particular, the clinical outcome for patients with …

Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many
new treatment methods have been developed during recent decades. The Japanese …

Background The triplet FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus
bevacizumab showed improved outcomes for patients with metastatic colorectal cancer …

Background Patients with peritoneal metastatic colorectal cancer have reduced overall
survival compared with patients with metastatic colorectal cancer without peritoneal …

In 2012, there were 447000 new cases of colorectal cancer (CRC) in Europe. CRC is the
second most frequent cancer and represents 13.2% and 12.7% of all cancer cases in men …

Colorectal cancer is a major cause of death in Japan, where it accounts for the largest
number of deaths from malignant neoplasms among women and the third largest number …