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The hallmarks of cancer: a long non-coding RNA point of view
With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …
analysis, it became obvious that the human genome contains much more than just protein …
Long noncoding RNAs and the genetics of cancer
Cancer is a disease of aberrant gene expression. While the genetic causes of cancer have
been intensively studied, it is becoming evident that a large proportion of cancer …
been intensively studied, it is becoming evident that a large proportion of cancer …
Long non-coding RNAs and cancer: a new frontier of translational research?
Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …
profile of the entire human genome. However, the extent of transcription and the function of …
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway
The Alternative Lengthening of Telomeres (ALT) pathway is a telomerase-independent
pathway for telomere maintenance that is active in a significant subset of human cancers …
pathway for telomere maintenance that is active in a significant subset of human cancers …
Mammalian telomeric RNA (TERRA) can be translated to produce valine–arginine and glycine–leucine dipeptide repeat proteins
Mammalian telomeres consist of (TTAGGG) n repeats. Transcription of the C-rich strand
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …
Alternative lengthening of telomeres: models, mechanisms and implications
Unlimited cellular proliferation depends on counteracting the telomere attrition that
accompanies DNA replication. In human cancers this usually occurs through upregulation of …
accompanies DNA replication. In human cancers this usually occurs through upregulation of …
[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
[HTML][HTML] The emerging roles of TERRA in telomere maintenance and genome stability
N Bettin, C Oss Pegorar, E Cusanelli - Cells, 2019 - mdpi.com
The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …
the roles of telomeric transcripts in chromosome end maintenance and genome stability …
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
B Balk, A Maicher, M Dees, J Klermund… - Nature structural & …, 2013 - nature.com
Although telomeres are heterochromatic, they are transcribed into noncoding telomeric
repeat–containing RNA (TERRA). Here we show that RNA-DNA hybrids form at telomeres …
repeat–containing RNA (TERRA). Here we show that RNA-DNA hybrids form at telomeres …
Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets
Long noncoding RNAs are emerging as key players in various fundamental biological
processes. We highlight the varied molecular mechanisms by which lncRNAs modulate …
processes. We highlight the varied molecular mechanisms by which lncRNAs modulate …