Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

This article gives an overview of recent progress in protein-protein docking and it identifies
several directions for future research. Recent results from the CAPRI blind docking …

The identification of proximate amino acids by chemical cross-linking and mass
spectrometry (XL-MS) facilitates the structural analysis of homogeneous protein complexes …

PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein in the
excitatory postsynaptic density (PSD) and a potent regulator of synaptic strength. Here we …

Traditional approaches to protein–protein docking sample the binding modes with no regard
to similar experimentally determined structures (templates) of protein–protein complexes …

The role of electrostatics in protein–protein interactions and binding is reviewed in this
paper. A brief outline of the computational modeling, in the framework of continuum …

To understand the cell, we need to determine the macromolecular assembly structures,
which may consist of tens to hundreds of components. First, we review the varied …

Protein docking algorithms aim to calculate the three‐dimensional (3D) structure of a protein
complex starting from its unbound components. Although ab initio docking algorithms are …

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic
neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a …

PSD-95 is a prominent organizer of the postsynaptic density (PSD) that can present a
filamentous orientation perpendicular to the plasma membrane. Interactions between PSD …