Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females

A Almey, TA Milner, WG Brake - Hormones and behavior, 2015‏ - Elsevier
This article is part of a Special Issue “Estradiol and cognition”. Over the past 30 years,
research has demonstrated that estrogens not only are important for female reproduction …

Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.

BS McEwen, KT Akama, JL Spencer-Segal… - Behavioral …, 2012‏ - psycnet.apa.org
From its origins in how the brain controls the endocrine system via the hypothalamus and
pituitary gland, neuroendocrinology has evolved into a science that now includes hormone …

Sex differences and the role of estradiol in mesolimbic reward circuits and vulnerability to cocaine and opiate addiction

SS Kokane, LI Perrotti - Frontiers in behavioral neuroscience, 2020‏ - frontiersin.org
Although both men and women become addicted to drugs of abuse, women transition to
addiction faster, experience greater difficulties remaining abstinent, and relapse more often …

Estrous cycle mediates midbrain neuron excitability altering social behavior upon stress

MR Shanley, Y Miura, CA Guevara… - Journal of …, 2023‏ - Soc Neuroscience
The estrous cycle is a potent modulator of neuron physiology. In rodents, in vivo ventral
tegmental area (VTA) dopamine (DA) activity has been shown to fluctuate across the estrous …

Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol

BJ Vandegrift, C You, R Satta, MS Brodie, AW Lasek - PloS one, 2017‏ - journals.plos.org
Gender differences in psychiatric disorders such as addiction may be modulated by the
steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of …

Characterization of aromatase expression in the adult male and female mouse brain. I. Coexistence with oestrogen receptors α and β, and androgen receptors

D Stanić, S Dubois, HK Chua, B Tonge, N Rinehart… - PloS one, 2014‏ - journals.plos.org
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that
local oestrogens influence many brain regions to modulate brain development and …

Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex-and region-specific manner

JS Carter, CC Costa, SI Lewandowski… - Translational …, 2024‏ - nature.com
Return to use, or relapse, is a major challenge in the treatment of opioid use disorder (OUD).
Relapse can be precipitated by several factors, including exposure to drug-conditioned …

Estrogen receptor β expression in the mouse forebrain: age and sex differences

DG Zuloaga, KL Zuloaga, LR Hinds… - Journal of …, 2014‏ - Wiley Online Library
Estrogen receptors regulate multiple brain functions, including stress, sexual, and memory‐
associated behaviors as well as controlling neuroendocrine and autonomic function. During …

Estrogen receptor α regulates ethanol excitation of ventral tegmental area neurons and binge drinking in female mice

BJ Vandegrift, ER Hilderbrand, R Satta… - Journal of …, 2020‏ - Soc Neuroscience
Elevations in estrogen (17β-estradiol, E2) are associated with increased alcohol drinking by
women and experimentally in rodents. E2 alters the activity of the dopamine system …

Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains

M Morishita, S Higo, K Iwata, H Ishii - Biology of sex Differences, 2023‏ - Springer
Background ESR2, a nuclear estrogen receptor also known as estrogen receptor β, is
expressed in the brain and contributes to the actions of estrogen in various physiological …