Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes
LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …
The coagulopathy, endotheliopathy, and vasculitis of COVID-19
Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the
elevated D-dimer without remarkable changes of other global coagulation markers is …
elevated D-dimer without remarkable changes of other global coagulation markers is …
Microvascular dysfunction in COVID-19: the MYSTIC study
Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
Every step of the way: integrins in cancer progression and metastasis
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …
Integrins are the main cellular adhesion receptors that through multifaceted roles as …
Role of angiopoietin-2 in vascular physiology and pathophysiology
Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
Endothelial damage in acute respiratory distress syndrome
The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …
endothelial cells that internally lines blood vessels and mediates key processes involved in …
Therapeutic targeting of the angiopoietin–TIE pathway
P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …
permeability and pathological vascular remodelling during inflammation, tumour …
Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability
YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice
Preclinical drug development studies currently rely on costly and time-consuming animal
testing because existing cell culture models fail to recapitulate complex, organ-level disease …
testing because existing cell culture models fail to recapitulate complex, organ-level disease …