Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that
has been thoroughly revised. Don and Judy Voet explain biochemical concepts while …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs)
respond to a variety of different external stimuli and activate G proteins. GPCRs share many …

Studying membrane proteins represents a major challenge in protein biochemistry, with one
of the major difficulties being the problems encountered when working outside the natural …

The activities of integral membrane proteins are often affected by the structures of the lipid
molecules that surround them in the membrane. One important parameter is the …

The analytic generalized Born approximation is an efficient electrostatic model that
describes molecules in solution. Here it is modified to permit a more accurate description of …

Detergents are indispensable in the isolation of integral membrane proteins from biological
membranes to study their intrinsic structural and functional properties. Solubilization …

ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the
cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP …

Lipid molecules bound to membrane proteins are resolved in some high-resolution
structures of membrane proteins. An analysis of these structures provides a framework …