The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

Hematological malignancy is a disease arisen by complicate reasons that seriously
endangers human health. The research on its pathogenesis and therapies depends on the …

CDK9 plays a vital role in regulating RNA transcription and significantly impacts the
expression of short-lived proteins such as Mcl-1 and c-Myc. Thus, targeting CDK9 holds …

Targeted therapy for triple-negative breast cancers (TNBC) remains a clinical challenge due
to tumour heterogeneity. Since TNBC have key features of transcriptionally addicted …

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous non-Hodgkin lymphoma originating
in the skin and invading the systemic hematopoietic system. Current treatments, including …

Metastasis remains the principal cause of cancer-related lethality despite advancements in
cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade …

Selective inhibition of the transcription elongation factor (P‐TEFb) complex represents a
promising approach in cancer therapy, yet CDK9 inhibitors (CDK9i) are currently limited …

Super enhancers are a unique class of enhancers that possess a distinct structure and
mechanism, which enable them to exhibit stronger gene transcription regulatory function …

Super-enhancers (SEs) represent a distinct category of cis-regulatory elements notable for
their robust transcriptional activation capabilities. In tumor cells, SEs intricately regulate the …

Regulated cell death (RCD) is a form of cell death that can be regulated by numerous
biomacromolecules. Accumulating evidence suggests that dysregulated expression and …