Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis
of cancer determining uncontrolled cellular proliferation. In normal cells, Cyclin D1 …

Cancer immunotherapies, such as immune checkpoint blockade and chimeric antigen
receptor (CAR) T cell therapy, have transformed clinical oncology. However, limited patient …

The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-
approved drug for the treatment of “alcohol-dependence”, is Cu2+-dependent, but the …

Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Increasing lines of evidence show that the malignant behavior of cancer is not exclusively
attributable to cancer cells but also radically influenced by cancerous stroma activity and …

Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Metastasis is the leading cause of breast cancer–related deaths. Cancer-associated
fibroblasts (CAFs), the predominant stromal cell type in the breast tumour microenvironment …