Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Background/purpose Melatonin, an indoleamine secreted by the pineal gland, plays a key
role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and …

Objective: Melatonin has been shown to be neuroprotective in animal models. The objective
of this study is to examine the effect of melatonin on clinical, biochemical …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of morbidity and
mortality in neonates. Because of high concentrations of sensitive immature cells, metal …

Therapeutic hypothermia is a standard of care for infants≥ 36 weeks gestational age (GA)
with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included …

Hypoxic ischemic encephalopathy (HIE) is a type of neonatal brain injury, which occurs due
to lack of supply and oxygen deprivation to the brain. It is associated with a high morbidity …

Hypoxic–ischemic brain damage is an alarming health and economic problem in spite of the
advances in neonatal care. It can cause mortality or detrimental neurological disorders such …

Oxidative stress (OS) is defined as an unbalance between prooxidant and antioxidant
factors that can lead to cellular and tissue damage. The newborn, especially if preterm, is …

Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …