Biology of prostate-specific antigen

SP Balk, YJ Ko, GJ Bubley - Journal of clinical oncology, 2003 - ascopubs.org
Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both
prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum …

Screening for prostate cancer

D Ilic, MM Neuberger, M Djulbegovic… - Cochrane database of …, 2013 - cochranelibrary.com
Background Any form of screening aims to reduce disease‐specific and overall mortality,
and to improve a person's future quality of life. Screening for prostate cancer has generated …

Mathematical model-driven deep learning enables personalized adaptive therapy

K Gallagher, MAR Strobl, DS Park, FC Spoendlin… - Cancer …, 2024 - aacrjournals.org
Standard-of-care treatment regimens have long been designed for maximal cell killing, yet
these strategies often fail when applied to metastatic cancers due to the emergence of drug …

Current status of biomarkers for prostate cancer

VM Velonas, HH Woo, CG dos Remedios… - International journal of …, 2013 - mdpi.com
Prostate cancer (PCa) is a leading cause of cancer-related death of men globally. Since its
introduction, there has been intense debate as to the effectiveness of the prostate specific …

A review on the clinical utility of PSA in cancer prostate

M Adhyam, AK Gupta - Indian journal of surgical oncology, 2012 - Springer
Prostate cancer has come to share the oncological centrestage among male cancers. The
availability of Serum Prostate Specific Antigen, PSA, as a marker has encouraged it's use to …

Screening for prostate cancer: an update of the evidence for the US Preventive Services Task Force

R Harris, KN Lohr - Annals of internal medicine, 2002 - acpjournals.org
Background: In US men, prostate cancer is the most common noncutaneous cancer and the
second leading cause of cancer death. Screening for prostate cancer is controversial …

Use of prostate-specific antigen (PSA) isoforms for the detection of prostate cancer in men with a PSA level of 2–10 ng/ml: systematic review and meta-analysis

AW Roddam, MJ Duffy, FC Hamdy, AM Ward, J Patnick… - European urology, 2005 - Elsevier
OBJECTIVE:: Measurement of serum prostate-specific antigen (PSA) for the detection of
prostate cancer has poor specificity in men with PSA levels between 2 and 10ng/ml. It has …

[PDF][PDF] Prostate testing for cancer and treatment (ProtecT) feasibility study

J Donovan, F Hamdy, D Neal, T Peters, S Oliver… - 2003 - academia.edu
Background There is currently insufficient evidence to introduce population screening for
prostate cancer. While it is accepted that prostate cancer is an important public health …

The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer

G Ayala, D Wang, G Wulf, A Frolov, R Li… - Cancer …, 2003 - aacrjournals.org
Prostate cancer (PCa) is the most common male cancer in the United States. A major
challenge that remains is to predict the clinical outcome in managing PCa patients. The …

Prostate biopsy: indications and technique

BR Matlaga, LA Eskew… - The Journal of urology, 2003 - auajournals.org
Purpose: The last decade has seen numerous modifications in the way prostate cancer is
diagnosed. We review the current indications for and methods of prostate biopsy. Materials …