A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

With advances in neonatal care, preterm neonates are surviving with an evolving
constellation of motor and cognitive disabilities that appear to be related to widespread …

Background Congenital heart disease in newborns is associated with global impairment in
development. We characterized brain metabolism and microstructure, as measures of brain …

Brain injury in the premature infant, a problem of enormous importance, is associated with a
high risk of neurodevelopmental disability. The major type of injury involves cerebral white …

Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-
OLs), is the most common form of injury to the preterm brain and is associated with a high …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

The neurodevelopmental disabilities of those who were born prematurely have been well
described, yet the underlying alterations in brain development that lead to these changes …

Experimental studies that are relevant to human pregnancy rely on the selection of
appropriate animal models as an important element in experimental design. Consideration …

Objective: Previously we reported that exposure of 6‐day‐old (P6) rhesus macaques to
isoflurane for 5 hours triggers a robust neuroapoptosis response in develo** brain. We …