Bisphosphonates—much more than only drugs for bone diseases

A Kuźnik, A Październiok-Holewa, P Jewula… - European journal of …, 2020 - Elsevier
Abstract α, α-Bisphosphonates (BPs) are well established in the treatment of bone diseases
such as osteoporosis and Paget's disease. Their successful application originates from their …

Asymmetric synthesis of chiral amino carboxylic‐phosphonic acid derivatives

HQ Cao, JK Li, FG Zhang, D Cahard… - Advanced Synthesis & …, 2021 - Wiley Online Library
Chiral amino acids featuring a phosphonate pendant arm are an important type of
biologically active scaffold. Here in this review, we comprehensively summarize the modern …

[HTML][HTML] Advanced material and approach for metal ions removal from aqueous solutions

PA Turhanen, JJ Vepsäläinen, S Peräniemi - Scientific reports, 2015 - nature.com
A Novel approach to remove metals from aqueous solutions has been developed. The
method is based on a resin free, solid, non-toxic, microcrystalline bisphosphonate material …

Nafion phosphonic acid composite membranes for proton exchange membranes fuel cells

FC Teixeira, AI de Sá, APS Teixeira, CM Rangel - Applied Surface Science, 2019 - Elsevier
In this work, new doped Nafion membranes with enhanced proton conductivity were
prepared to be used as proton exchange membranes in fuel cells. New dopants derived …

N-heterocyclic dronic acids: applications and synthesis

H R. Hudson, N J. Wardle, S WA Bligh… - Mini reviews in …, 2012 - benthamdirect.com
Substituted hydroxymethylenebisphosphonic acid derivatives–either as dronic acids or their
dronate sodium salts, are important pharmaceuticals in the treatment of diseases arising …

Effects of soil amendments on the growth response and phytoextraction capability of a willow variety (S. viminalis× S. schwerinii× S. dasyclados) grown in …

MMA Salam, M Mohsin, P Pulkkinen… - Ecotoxicology and …, 2019 - Elsevier
This study was conducted to evaluate the effects of lime and bisphosphonates (BPs) such as
N10O chelate amendment on the growth, physiological and biochemical parameters, and …

ZnCl2-Mediated Double Addition of Dialkylphosphite to Nitriles for the Synthesis of 1-Aminobisphosphonates

B Kaboudin, H Esfandiari, A Moradi… - The Journal of …, 2019 - ACS Publications
In this study, the double addition of dialkylphosphite to nitriles in a ZnCl2/Et3N system is
described. The reaction was conveniently and directly used for the synthesis of biologically …

Betulin phosphonates; synthesis, structure, and cytotoxic activity

E Chrobak, E Bębenek, M Kadela-Tomanek, M Latocha… - Molecules, 2016 - mdpi.com
Betulin derivatives are a widely studied group of compounds of natural origin due to their
wide spectrum of biological activities. This paper describes new betulin derivatives …

Synthetic procedures leading towards aminobisphosphonates

E Chmielewska, P Kafarski - Molecules, 2016 - mdpi.com
Growing interest in the biological activity of aminobisphosphonates has stimulated the
development of methods for their synthesis. Although several general procedures were …

General and chemoselective bisphosphonylation of secondary and tertiary amides

AE Wang, Z Chang, WT Sun, PQ Huang - Organic letters, 2015 - ACS Publications
With Tf2O as the activation reagent, a mild and general method has been developed for the
bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient …