Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Subclonal cancer populations change spatially and temporally during the disease course.
Studies are revealing branched evolutionary cancer growth with low-frequency driver events …

Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …

Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including
structural variations (SVs) and copy number alterations (CNAs). To define the landscape of …

Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which
multiple same-strand substitutions at C: G pairs spaced one to several hundred nucleotides …

The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously
damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why …

Clusters of simultaneous multiple mutations can be a source of rapid change during
carcinogenesis and evolution. Such mutation clusters have been recently shown to originate …

Adaptive immunity in jawless fishes is based on antigen recognition by three types of
variable lymphocyte receptors (VLRs) composed of variable leucine-rich repeats, which are …

Mutations are the basis for evolution and the development of genetic diseases. Especially in
cancer, somatic mutations in oncogenes and tumor suppressor genes alongside the …

APOBEC enzymes are responsible for a mutation signature (TCW> T/G) implicated in a wide
variety of tumors. We explore the APOBEC mutational signature in bladder cancer and the …