The Smad dependent TGF-β and BMP signaling pathway in bone remodeling and therapies

ML Zou, ZH Chen, YY Teng, SY Liu, Y Jia… - Frontiers in molecular …, 2021 - frontiersin.org
Bone remodeling is a continuous process that maintains the homeostasis of the skeletal
system, and it depends on the homeostasis between bone-forming osteoblasts and bone …

Neuroprotection by agmatine: Possible involvement of the gut microbiome?

P Saha, S Panda, A Holkar, R Vashishth… - Ageing Research …, 2023 - Elsevier
Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Agmatine modulation of gut-brain axis alleviates dysbiosis-induced depression-like behavior in rats

S Rahangdale, P Deshmukh, S Sammeta… - European Journal of …, 2024 - Elsevier
Depression is a global health concern affecting nearly 280 million individuals. It not only
imposes a significant burden on economies and healthcare systems but also manifests …

Neuroprotective offerings by agmatine

NR Kotagale, BG Taksande, NN Inamdar - Neurotoxicology, 2019 - Elsevier
Agmatine, an endogenous polyamine in CNS, is derived from arginine by dearboxylation.
Like polyamines, agmatine has been studied for its neuroprotetive effects. At present, a large …

Astrocyte and oligodendrocyte responses from the subventricular zone after injury

J David-Bercholz, CT Kuo, B Deneen - Frontiers in Cellular …, 2021 - frontiersin.org
Under normal conditions, neural stem cells (NSCs or B cells) in the adult subventricular
zone (SVZ) give rise to amplifying neural progenitor cells (NPCs or C cells), which can …

The neuroprotective effects of agmatine on Parkinson's disease: Focus on oxidative stress, inflammation and molecular mechanisms

MY Zamanian, M Nazifi, LG Khachatryan, N Taheri… - Inflammation, 2024 - Springer
Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown
significant potential for neuroprotection in Parkinson's Disease (PD) due to its multifaceted …

Therapeutic potential of agmatine for CNS disorders

VB Neis, PB Rosa, G Olescowicz… - Neurochemistry …, 2017 - Elsevier
Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling
pathways. Several studies have focused on elucidating the mechanisms underlying the …

[HTML][HTML] Evidence for safety of the dietary ingredient agmatine sulfate as assessed by mutagenicity and genotoxicity studies

VH Gilad, E Béres, A Vértesi, G Hirka, GM Gilad - Toxicology Reports, 2024 - Elsevier
Abstract Agmatine, 1-Amino-4-guanidinobutane, is a ubiquitous naturally occurring
molecule present in low amounts in a wide variety of foodstuff. Clinical trials have …

Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of ischemic stroke

SJ Wen, XM Zheng, LF Liu, NN Li, HA Mao… - Neural Regeneration …, 2021 - journals.lww.com
Transplantation of neural stem cells (NSCs) can protect neurons in animal stroke models;
however, their low rates of survival and neuronal differentiation limit their clinical application …

Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome

Q Wei, X Hao, BWM Lau, S Wang, Y Li - Frontiers in Pharmacology, 2022 - frontiersin.org
It is widely acknowledged that the climacteric syndrome negatively affects women's quality of
life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of …