Molecular mechanism of doxorubicin-induced cardiomyopathy–An update
Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …
Doxorubicin‐induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy
FS Carvalho, A Burgeiro, R Garcia… - Medicinal research …, 2014 - Wiley Online Library
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy
N Ta, C Qu, H Wu, D Zhang, T Sun… - Proceedings of the …, 2022 - National Acad Sciences
Ferroptosis is an iron-dependent programmed necrosis characterized by glutathione (GSH)
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …
depletion and lipid peroxidation (LPO). Armed with both the pro-and antiferroptosis …
Doxorubicin: the good, the bad and the ugly effect
The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …
Updates in anthracycline-mediated cardiotoxicity
CG Nebigil, L Désaubry - Frontiers in Pharmacology, 2018 - frontiersin.org
Cardiotoxicity is one of the main adverse effects of chemotheraphy, affecting the completion
of cancer therapies and the short-and long-term quality of life. Anthracyclines are currently …
of cancer therapies and the short-and long-term quality of life. Anthracyclines are currently …
Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …
Metabolic aspects of anthracycline cardiotoxicity
Opinion statement Heart failure (HF) is increasingly recognized as the major complication of
chemotherapy regimens. Despite the development of modern targeted therapies such as …
chemotherapy regimens. Despite the development of modern targeted therapies such as …
Astaxanthin ameliorates doxorubicin-induced cognitive impairment (chemobrain) in experimental rat model: impact on oxidative, inflammatory, and apoptotic …
Chemobrain refers to a common sequelae experienced by 15–80% of cancer patients
exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been …
exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been …
An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients
Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical
use is limited by toxicity. Different strategies have been proposed to attenuate toxicity …
use is limited by toxicity. Different strategies have been proposed to attenuate toxicity …
Mechanisms of chemotherapy-induced behavioral toxicities
EG Vichaya, GS Chiu, K Krukowski… - Frontiers in …, 2015 - frontiersin.org
While chemotherapeutic agents have yielded relative success in the treatment of cancer,
patients are often plagued with unwanted and even debilitating side-effects from the …
patients are often plagued with unwanted and even debilitating side-effects from the …