In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Despite therapeutic advancements, disease-free survival and overall survival of patients
with locally advanced rectal cancer have not improved in most trials as a result of distant …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

Clinical trials frequently include multiple end points that mature at different times. The initial
report, typically based on the primary end point, may be published when key planned co …

Background Organ preservation after reaching clinical complete response on neoadjuvant
therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is …

The determination of an optimal treatment plan for an individual patient with rectal cancer is
a complex process. In addition to decisions relating to the intent of rectal cancer surgery (ie …

The incidence of rectal cancer is increasing in patients younger than 50 years. Locally
advanced rectal cancer is still treated with neoadjuvant radiation, chemotherapy and …

Background The current standard treatment for locally advanced rectal cancer is
neoadjuvant chemoradiotherapy followed by radical surgery, but this approach can lead to …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

Importance Assessing clinical tumor response following completion of total neoadjuvant
therapy (TNT) in patients with locally advanced rectal cancer is paramount to select patients …