Rapidly progressive dementias (RPDs) are a group of heterogeneous disorders that include
immune-mediated, infectious and metabolic encephalopathies, as well as prion diseases …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …

Background Definite diagnosis of sporadic Creutzfeldt–Jakob disease in living patients
remains a challenge. A test that detects the specific marker for Creutzfeldt–Jakob disease …

Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …

Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by
inflammatory, cancer and stem cells. Its physiological role is not completely understood but …

Objective Several prion amplification systems have been proposed for detection of prions in
cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with …

Abstract Purpose of Review: This article presents an update on the clinical aspects of human
prion disease, including the wide spectrum of their presentations. Recent Findings: Prion …

Importance Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is
necessary for quickly distinguishing treatable from untreatable rapidly progressive …

An early and accurate in vivo diagnosis of rapidly progressive dementia remains
challenging, despite its critical importance for the outcome of treatable forms, and the …