Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The role of the serine/threonine protein kinase B (PKB, also known as Akt) is becoming
increasingly more evident to researchers investigating diverse cellular processes such as …

Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-
range of cancers, accounting for 5% of all human cancers. A prominent example is cervical …

The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular
signals and involved in a number of cellular processes including cell proliferation, survival …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key cascade downstream
of several protein kinases, especially membrane-bound receptor tyrosine kinases, including …