Network medicine and systems pharmacology approaches to predicting adverse drug effects
Identifying and understanding the relationships between drug intake and adverse effects
that can occur due to inadvertent molecular interactions between drugs and targets is a …
that can occur due to inadvertent molecular interactions between drugs and targets is a …
Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain–containing CAR
SA Ritmeester-Loy, IH Draper, EC Bueter, JD Lautz… - Science …, 2024 - science.org
Cells rely on activity-dependent protein-protein interactions to convey biological signals. For
chimeric antigen receptor (CAR) T cells containing a 4-1BB costimulatory domain, receptor …
chimeric antigen receptor (CAR) T cells containing a 4-1BB costimulatory domain, receptor …
How far are we from the completion of the human protein interactome reconstruction?
After more than fifteen years from the first high-throughput experiments for human protein–
protein interaction (PPI) detection, we are still wondering how close the completion of the …
protein interaction (PPI) detection, we are still wondering how close the completion of the …
MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia
Abstract DNMT3A and IDH1/2 mutations combinatorically regulate the transcriptome and the
epigenome in acute myeloid leukemia; yet the mechanisms of this interplay are unknown …
epigenome in acute myeloid leukemia; yet the mechanisms of this interplay are unknown …
Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis
Although cyclosporine comprises a well-established systemic therapy for psoriasis, patients
show important heterogeneity in their treatment response. The aim of our study was the …
show important heterogeneity in their treatment response. The aim of our study was the …