The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA
selection and translocation reactions that proceed rapidly (2–20 per second) and with a low …

Faithful translation of messenger RNA (mRNA) into protein is essential to maintain protein
homeostasis in the cell. Spontaneous translation errors are very rare due to stringent …

Eukaryotic ribosomes are substantially larger and more complex than their bacterial
counterparts. Although their core function is conserved, bacterial and eukaryotic protein …

Ribosome stalling during translation is detrimental to cellular fitness, but how this is sensed
and elicits recycling of ribosomal subunits and quality control of associated mRNA and …

Protein synthesis is one of the major targets in the cell for antibiotics. This review endeavors
to provide a comprehensive “post-ribosome structure” A–Z of the huge diversity of antibiotics …

The sequential addition of amino acids to a growing polypeptide chain is carried out by the
ribosome in a complicated multistep process called the elongation cycle. It involves accurate …

Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial
ribosomes and the translational machinery represent one of the major targets for antibiotics …