Structural mass spectrometry (MS) is gaining increasing importance for deriving valuable
three‐dimensional structural information on proteins and protein complexes, and it …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Hepatocarcinogenesis is a multistep process mainly associated with persistent infection with …

Two main causes of platinum resistance are mutation in the tumor suppressor gene TP53
and drug-induced increase in intracellular glutathione concentration. Mutations in TP53 …

Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …

The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”;
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity …

Despite the recent rapid progress in cryo-electron microscopy (cryo-EM), there still exist
ample opportunities for improvement in sample preparation. Macromolecular complexes …

Combining the properties of a zero‐length cross‐linker with cleavability by tandem mass
spectrometry (MS/MS) poses great advantages for protein structure analysis using the cross …

The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a
cornucopia of activities and regulatory pathways have been associated with it. In this review …

Abstract Li-Fraumeni Syndrome (LFS) results from heterozygous germline mutations of
TP53, encoding a key transcriptional factor activated in response to DNA damage. We have …

p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to
cancer. This tumour suppressor protein has three main domains; the N-terminal …