Coumarin: A natural, privileged and versatile scaffold for bioactive compounds
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
Biological importance of structurally diversified chromenes
Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …
display a wide variety of biological activities. Their low toxicity combined to the broad …
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs
Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two
coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X …
coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X …
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
SS ** novel coumarin-containing azoles antifungal agents by the scaffold merging strategy for treating azole-resistant candidiasis
Z Yan, Y Huang, D Zhao, Z Li, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
The extensive use of antifungal drugs has resulted in severe drug resistance, making clinical
treatment of fungal infections more difficult. Biofilm inhibitors can overcome drug resistance …
treatment of fungal infections more difficult. Biofilm inhibitors can overcome drug resistance …
Monoamine oxidase (MAO) as a potential target for anticancer drug design and development
Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of
biogenic amines into their corresponding aldehydes and ketones through oxidative …
biogenic amines into their corresponding aldehydes and ketones through oxidative …
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
RKP Tripathi, SR Ayyannan - Medicinal research reviews, 2019 - Wiley Online Library
Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …
indispensable approach of molecular and mechanistic diversity for the discovery of …
Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update
M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …
Currently, no effective treatment is available and this is due to multiple factors involved in …