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[HTML][HTML] The current state of animal models in research: A review
NB Robinson, K Krieger, FM Khan, W Huffman… - International Journal of …, 2019 - Elsevier
Animal models have provided invaluable information in the pursuit of medical knowledge
and alleviation of human suffering. The foundations of our basic understanding of disease …
and alleviation of human suffering. The foundations of our basic understanding of disease …
[HTML][HTML] Sudden cardiac death: epidemiology, pathogenesis and management
Sudden cardiac death (SCD) is an unexpected sudden death due to a heart condition, that
occurs within one hour of symptoms onset. SCD is a leading cause of death in western …
occurs within one hour of symptoms onset. SCD is a leading cause of death in western …
Pathological ventricular remodeling: mechanisms: part 1 of 2
Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
Animal models of arrhythmia: classic electrophysiology to genetically modified large animals
Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
Sudden cardiac death
DP Zipes, HJJ Wellens - Circulation, 1998 - ahajournals.org
heart disease increases with age (Figure 2). However, among patients with coronary heart
disease, the proportion of coronary deaths that are sudden decreases with age. Sudden …
disease, the proportion of coronary deaths that are sudden decreases with age. Sudden …
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort
Background—Studies of atrial fibrillation (AF) due to atrial tachycardia have provided
insights into the remodeling mechanisms by which “AF begets AF” but have not elucidated …
insights into the remodeling mechanisms by which “AF begets AF” but have not elucidated …
Molecular mechanisms of myocardial remodeling
B Swynghedauw - Physiological reviews, 1999 - journals.physiology.org
Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …
Ion channels in the heart
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
regions of the heart, as well as on appropriate heart rate. This is accomplished via …
Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation
Rapid electrical activation, as occurs during atrial fibrillation (AF), is known to cause
reductions in atrial refractoriness and in adaptation to heart rate of the atrial refractory …
reductions in atrial refractoriness and in adaptation to heart rate of the atrial refractory …