In this review we have selected some notable examples of azoles and nitroimidazoles and
their coordination compounds with previously reported biological effectiveness. In an effort …

An organophotoredox-catalyzed decarboxylative cross-coupling between azole
nucleophiles and aliphatic carboxylic acid-derived redox-active esters is demonstrated. This …

Lactam-containing structural compounds are ubiquitous in drugs and biomolecules. An
electrochemical oxidative direct C (sp3)–H azolation of lactams has been reported under …

A method for regioselective N-alkylation of ambident, azole-type heterocycles with alkene or
epoxide electrophiles is described. In the presence of diphenylborinic acid (Ph2BOH) and …

Microorganisms have a close relationship with humans, whether it is commensal, symbiotic,
or pathogenic. Recently, it has been documented that microorganisms may influence the …

Pathogenic fungi exhibit a heavy burden on medical care and new therapies are needed.
Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic …

An experimental approach is described for late-stage lead diversification of frontrunner drug
candidates using nanomole-scale amounts of lead compounds for structure–activity …

Like human, fungi too are known to share lot of structural similarities amongst their CYPs
(Cytochrome P450 super family of enzymes) which allows antifungal 'azole'compounds to …

A highly efficient iodide ion (I–)-promoted method for direct α-C (sp2)–H triazolization of
aldehydes has been developed for the regioselective synthesis of N 2-substituted triazole …

The emergence of resistance to nearly every therapeutic agent directed against malaria-
causing Plasmodium parasites emphasises the dire need for new antimalarials. Despite …