The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-
characterized inbred strains of mice that can be used to analyze the genetic and …

Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal.
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Age-related hearing loss (ARHL) is a prevalent concern in the elderly population. Recent
genome-wide and phenome-wide association studies (GWASs and PheWASs) have delved …

We studied sex differences in over 50 cardio-metabolic traits in a panel of 100 diverse
inbred strains of mice. The results clearly showed that the effects of sex on both clinical …

Common forms of atherosclerosis involve multiple genetic and environmental factors. While
human genome-wide association studies have identified numerous loci contributing to …

Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more
common in women than men, and we hypothesize that mitochondrial sex differences might …

We report the genetic analysis of a “humanized” hyperlipidemic mouse model for
progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for …

We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-
induced heart failure model in mice, which allowed control of confounding factors in an …

Somatic polyploidization, an adaptation by which cells increase their DNA content to support
growth, is observed in many cell types, including cardiomyocytes. Although polyploidization …