Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an
attractive family of substances that can potentially be used for the clinical treatment of cancer …

Sialic acid at the terminus of cell surface glycoconjugates is a critical element in cell-cell
recognition, receptor binding and immune responses. Sialyltransferases (ST), the enzymes …

Sialic acid occupies a privileged position at the terminus of the glycan chain of many cell-
surface glycoconjugates. Owing to both their structure and location, charged sialic acid …

The critical role of sialyltransferase (ST) enzymes in tumour cell growth and metastasis, as
well as links to multi-drug and radiation resistance, has seen STs emerge as a target for …

Tumour‐derived sialoglycans, bearing the charged nonulosonic sugar sialic acid at their
termini, play a critical role in tumour cell adhesion and invasion, as well as evading cell …

Shanghai, a city situated on the estuary of Yangtze River in east China (Figure 1), welcomed
a gathering of diverse chemical biologists from around the globe at the sixth annual …

In contrast to humans that generate only a single type of polymer consisting of α2, 8-linked N-
acetylneuraminic acid polyNeu5Ac, fishes are able to generate a wide range of different …