Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

In response to stress, human cells coordinately downregulate transcription and translation of
housekee** genes. To downregulate transcription, the negative elongation factor (NELF) …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-
regulated immune evasion mechanisms, we identified an evolutionarily conserved function …

Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage
(2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such …

SUMOylation—the attachment of a small ubiquitin-like modifier (SUMO) to target proteins—
plays roles in controlling plant growth, nutrient signalling and stress responses …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …