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Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology
Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …
clinically and economically as it prevails in poorer countries and regions, strongly hindering …
Revisiting gametocyte biology in malaria parasites
Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito
vector. They are present at low levels in blood circulation and significant knowledge gaps …
vector. They are present at low levels in blood circulation and significant knowledge gaps …
[HTML][HTML] Identification of a master regulator of differentiation in Toxoplasma
Toxoplasma gondii chronically infects a quarter of the world's population, and its
recrudescence can cause life-threatening disease in immunocompromised individuals and …
recrudescence can cause life-threatening disease in immunocompromised individuals and …
Dissecting the role of PfAP2-G in malaria gametocytogenesis
In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to
sexual differentiation into gametocytes is essential for transmission to mosquitos. The …
sexual differentiation into gametocytes is essential for transmission to mosquitos. The …
A transcriptional switch controls sex determination in Plasmodium falciparum
Sexual reproduction and meiotic sex are deeply rooted in the eukaryotic tree of life, but
mechanisms determining sex or mating types are extremely varied and are only well …
mechanisms determining sex or mating types are extremely varied and are only well …
[HTML][HTML] ApiAP2 transcription factors in apicomplexan parasites
Apicomplexan parasites are protozoan organisms that are characterised by complex life
cycles and they include medically important species, such as the malaria parasite …
cycles and they include medically important species, such as the malaria parasite …
A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum
Gametocytogenesis, the process by which malaria parasites produce sexual forms that can
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
infect mosquitoes, is essential for the transmission of malaria. A transcriptional switch of the …
A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures
E Tintó-Font, L Michel-Todó, TJ Russell… - Nature …, 2021 - nature.com
Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive
febrile episodes is not known. Although the genomes of Plasmodium species encode a full …
febrile episodes is not known. Although the genomes of Plasmodium species encode a full …
[HTML][HTML] The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development
WL Mandala, V Harawa, F Dzinjalamala… - Molecular and …, 2021 - Elsevier
Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …
[HTML][HTML] Regulation of sexual commitment in malaria parasites—a complex affair
TS Voss, NMB Brancucci - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Malaria blood stage parasites produce sexual transmission stages at variable
rates.•Commitment and conversion to the sexual path are under epigenetic control.•Sexual …
rates.•Commitment and conversion to the sexual path are under epigenetic control.•Sexual …