Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Personalized medicine promises individualized disease prediction and treatment. The
convergence of machine learning (ML) and available multimodal data is key moving …

Neurodegenerative diseases (NDD) are progressive degenerative disorders of the
neurological system with significant social impact worldwide. Their detection at the initial …

Stress affects cognition, behavior, and physiology, leading to lasting physical and mental
illness. The ability to detect and measure stress, however, is poor. Increased circulating …

Abstract Background The NIA-AA research framework proposes a purely biological
definition of Alzheimer's disease (AD). This implies that AD can be diagnosed based on …

Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Treatments for neurodegenerative disorders remain rare, but recent FDA approvals, such as
lecanemab and aducanumab for Alzheimer disease (MIM: 607822), highlight the importance …

Health systems around the world seek to address patients' unmet health needs for a range
of acute and chronic diseases. Simultaneously, governments strive to keep healthcare …