[LIBRO][B] Bioassay techniques for drug development
MI Choudhary, WJ Thomsen - 2001 - taylorfrancis.com
The goal of an activity-directed isolation process is to isolate bioactive compounds which
may provide structural leads of therapeutic importance. Whereas the traditional process of …
may provide structural leads of therapeutic importance. Whereas the traditional process of …
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
Y Hoshino, T Mio, S Nagai, H Miki… - American Journal of …, 2001 - journals.physiology.org
Injury of the alveolar epithelium by cigarette smoke is presumed to be an important process
in the pathogenesis of smoking-related pulmonary diseases. We investigated the cytotoxic …
in the pathogenesis of smoking-related pulmonary diseases. We investigated the cytotoxic …
Spectral profiles of cultured neuronal and glial cells derived from HRMAS 1H NMR spectroscopy
In the investigations of brain function and pathology in vivo by magnetic resonance
spectroscopy (MRS), a decrease in the relative concentration of N‐acetyl aspartate (NAA) …
spectroscopy (MRS), a decrease in the relative concentration of N‐acetyl aspartate (NAA) …
Gradient, high‐resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells
P Weybright, K Millis, N Campbell… - Magnetic resonance …, 1998 - Wiley Online Library
The application of new gradient, high‐resolution, magic angle spinning (MAS) 1H nuclear
magnetic resonance (NMR) spectroscopy to the study of intact undifferentiated and …
magnetic resonance (NMR) spectroscopy to the study of intact undifferentiated and …
A novel method of magnetic nanoparticles functionalized with anti-folate receptor antibody and methotrexate for antibody mediated targeted drug delivery
Therapeutic effects of anticancer medicines can be improved by targeting the specific
receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective …
receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective …
Genotoxic effects of chromium (VI) and cadmium (II) in human blood lymphocytes using the electron microscopy in situ end-labeling (EM-ISEL) assay
F Depault, M Cojocaru, F Fortin, S Chakrabarti… - Toxicology in vitro, 2006 - Elsevier
Evaluation of genotoxic effects of potassium chromate (K2CrO4) and cadmium chloride
(CdCl2) was carried out in human blood lymphocytes in vitro as measured by the electron …
(CdCl2) was carried out in human blood lymphocytes in vitro as measured by the electron …
An MTT‐based method for quantification of periodontal ligament cell viability
Objective: Survival of periodontal ligament cells is crucial issue after tooth replantation. To
understand this matter, we introduced MTT assay, which can be used as a tool for …
understand this matter, we introduced MTT assay, which can be used as a tool for …
A tetrazolium-based colorimetric assay for metabolic activity of stored blood platelets
Y Maekawa, K Yagi, A Nonomura, R Kuraoku… - Thrombosis research, 2003 - Elsevier
Introduction: Much work has been carried out in an attempt to establish the optimum
cryopreservation of platelets. To estimate the surviving numbers of stored platelets, the …
cryopreservation of platelets. To estimate the surviving numbers of stored platelets, the …
Modulation of polymorphonuclear cell interleukin-8 secretion by human monoclonal antibodies to type 8 pneumococcal capsular polysaccharide
T Burns, Z Zhong, M Steinitz, L Pirofski - Infection and immunity, 2003 - Am Soc Microbiol
Pneumococcal capsular polysaccharide (PS) vaccines induce type-specific immunoglobulin
M (IgM), IgG, and IgA. Type-specific IgG to the PS is sufficient to confer protection against the …
M (IgM), IgG, and IgA. Type-specific IgG to the PS is sufficient to confer protection against the …
The MPTP status during early reoxygenation is critical for cardioprotection
MA Husainy, JM Dickenson, M Galiñanes - Journal of Surgical Research, 2012 - Elsevier
BACKGROUND: Previous studies have revealed that the mitochondrial permeability
transition pore (MPTP) plays a critical role in necrotic and apoptotic cell death. Given the …
transition pore (MPTP) plays a critical role in necrotic and apoptotic cell death. Given the …