mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications
G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus,
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …
Low back pain
Low back pain covers a spectrum of different types of pain (eg, nociceptive, neuropathic and
nociplastic, or non-specific) that frequently overlap. The elements comprising the lumbar …
nociplastic, or non-specific) that frequently overlap. The elements comprising the lumbar …
Prehabilitation for patients undergoing orthopedic surgery: a systematic review and meta-analysis
Importance Prehabilitation programs for patients undergoing orthopedic surgery have been
gaining popularity in recent years. However, the current literature has produced varying …
gaining popularity in recent years. However, the current literature has produced varying …
[HTML][HTML] More treatment but no less depression: The treatment-prevalence paradox
Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …
since the 1980s. Mysteriously the general population prevalence of depression has not …
[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
Precision medicine in the era of artificial intelligence: implications in chronic disease management
Aberrant metabolism is the root cause of several serious health issues, creating a huge
burden to health and leading to diminished life expectancy. A dysregulated metabolism …
burden to health and leading to diminished life expectancy. A dysregulated metabolism …
Artificial intelligence in psychiatry research, diagnosis, and therapy
J Sun, QX Dong, SW Wang, YB Zheng, XX Liu… - Asian Journal of …, 2023 - Elsevier
Psychiatric disorders are now responsible for the largest proportion of the global burden of
disease, and even more challenges have been seen during the COVID-19 pandemic …
disease, and even more challenges have been seen during the COVID-19 pandemic …