Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells
driven by mutations in the mitogen-activated protein kinase pathway. When disease involves …

Abstract Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells
which may affect any organ of the body. Most of the knowledge about the diagnosis and …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

Abstract “Langerhans cell histiocytosis”(LCH) describes a spectrum of clinical presentations
ranging from a single bone lesion or trivial skin rash to an explosive disseminated disease …

Hypophysitis is a rare condition characterised by inflammation of the pituitary gland, usually
resulting in hypopituitarism and pituitary enlargement. Pituitary inflammation can occur as a …

Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include
Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due …

Hypopituitarism includes all clinical conditions that result in partial or complete failure of the
anterior and posterior lobe of the pituitary gland's ability to secrete hormones. The aim of …

Denosumab (Dmab), a monoclonal antibody against the receptor activator of nuclear factor-
κB (RANK) ligand (RANKL) which substantially suppresses osteoclast activity, has been …

Inflammatory and granulomatous diseases of the pituitary are rare causes of sellar masses.
Lymphocytic hypophysitis is the most relevant of these disorders, and it is characterised by …

Abstract Context: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell
histiocytosis, characterized by infiltration of foamy histiocytes in multiple organs. Endocrine …