Muscle contraction and relaxation are regulated by the myoplasmic free calcium
concentration, which in turn is regulated by membranes. Sarco plasmic reticulum (SR) has a …

This paper describes the distribution of structures stained with mono-and polyclonal
antibodies to the calcium-binding proteins calbindin D-28k and parvalbumin in the nervous …

Block of Ca2+ currents by the dihydropyridine drug nitrendipine was studied in single canine
ventricular cells by using the whole-cell variant of the patch clamp technique. When cells …

Aldosterone is a hormone that exerts manifold deleterious effects on the kidneys, blood
vessels, and heart which can lead to pathophysiological consequences. Inhibition of the …

Activators and blockers of specific ion channels are important pharmacological tools for
characterizing ion channels and their influence on cell function. The large-conductance Ca …

Limitations of current steroidal mineralocorticoid receptor (MR) antagonists have stimulated
the search for a new generation of molecules. We screened for novel nonsteroidal …

Safety assessment of pharmaceuticals is a rapidly develo** area of pharmacy and
medicine. The new advanced guidelines for testing the toxicity of compounds require …

Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been
one of the most active areas of molecular neuroscience during the past decade. This work …

Chronic ingestion of caffeine by male NIH strain mice alters the density of a variety of central
receptors. 2. The density of cortical A 1 adenosine receptors is increased by 20%, while the …

The richest source of receptors for the organic calcium channel blocker [3H] nitrendipine in
muscle is the transverse tubule membrane. The tubular membrane preparation binds [3H] …