The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large
interpatient variability in the dose required to achieve target anticoagulation. Common …

Interindividual variability in drug response is a major clinical problem. Polymedication and
genetic polymorphisms modulating drug-metabolising enzyme activities (cytochromes P450 …

Objectives This review attempts to bring together information from a large number of recent
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …

The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Differences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework …

We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …

Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

Although nonsteroidal antiinflammatory drugs can alleviate menstrual pain, about 18% of
women with dysmenorrhea are unresponsive, leaving them and their physicians to pursue …