Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Dynamic changes of the lengths of mRNA poly (A) tails are catalysed by diverse
deadenylase enzymes. Modulating the length of the poly (A) tail of an mRNA is a …

Peroxisome proliferator-activated receptor γ (PPARγ) is a critical factor for adipogenesis and
glucose metabolism, but accumulating evidence demonstrates the involvement of PPARγ in …

Circadian clocks are self-sustaining genetically based molecular machines that impose∼
24h rhythmicity on physiology and behavior that synchronize these functions with the solar …

Edery, Isaac. Circadian rhythms in a nutshell. Physiol Genomics 3: 59–74, 2000.—Living
organisms on this planet have adapted to the daily rotation of the earth on its axis. By means …

Circadian rhythms exist in most living organisms. The general molecular mechanisms that
are used to generate 24-hour rhythms are conserved among organisms, although the details …

Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here
we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex …

We report the characterization of a novel Drosophila circadian clock-regulated output gene,
takeout (to). The to amino acid sequence shows similarity to two ligand binding proteins …

The process of mRNA decay is integral to the post-transcriptional control of gene
expression. The enzymes of the pathway have been identified, and now several laboratories …

Abstract Circadian (24-h) clocks are cell-autonomous biological oscillators that orchestrate
many aspects of our physiology on a daily basis. Numerous circadian rhythms in …