Particle detection and characterization for biopharmaceutical applications: current principles of established and alternative techniques

J Gross-Rother, M Blech, E Preis, U Bakowsky… - Pharmaceutics, 2020 - mdpi.com
Detection and characterization of particles in the visible and subvisible size range is critical
in many fields of industrial research. Commercial particle analysis systems have proliferated …

[HTML][HTML] Determination of Hansen parameters for particles: A standardized routine based on analytical centrifugation

S Süß, T Sobisch, W Peukert, D Lerche… - Advanced Powder …, 2018 - Elsevier
Abstract The Hansen Solubility Parameters (HSP) are powerful descriptors to evaluate
interactions of (polymer) molecules and their solubility in different liquids. Although …

AAV analysis by sedimentation velocity analytical ultracentrifugation: beyond empty and full capsids

AE Yarawsky, V Zai-Rose, HM Cunningham… - European Biophysics …, 2023 - Springer
The recent surge of therapeutic interest in recombinant adeno-associated viral (AAV) vectors
for targeted DNA delivery has brought analytical ultracentrifugation (AUC) into the spotlight …

Multidimensional characterization of noble metal alloy nanoparticles by multiwavelength analytical ultracentrifugation

PC Lopez, MJ Uttinger, NE Traoré, HA Khan, D Drobek… - Nanoscale, 2022 - pubs.rsc.org
In this study, we introduce a method for the simultaneous retrieval of two-dimensional size-
composition distributions of noble metal Ag–Au alloy nanoparticles utilizing an analytical …

Determination of 2D particle size distributions in plasmonic nanoparticle colloids via analytical ultracentrifugation: Application to gold bipyramids

U Frank, D Drobek, A Sánchez-Iglesias, SE Wawra… - ACS …, 2023 - ACS Publications
Multidimensional particle properties determine the product properties in numerous
advanced applications. Accurate and statistically meaningful measurements of complex …

Classification and characterization of multimodal nanoparticle size distributions by size-exclusion chromatography

L Gromotka, MJ Uttinger, C Schlumberger, M Thommes… - Nanoscale, 2022 - pubs.rsc.org
Size-exclusion chromatography (SEC) is a well-known, versatile and scalable technique for
the separation of molecules according to their hydrodynamic size in solution as well as for …

Determination of the two-dimensional distributions of gold nanorods by multiwavelength analytical ultracentrifugation

SE Wawra, L Pflug, T Thajudeen, C Kryschi… - Nature …, 2018 - nature.com
Abstract Properties of nanoparticles are influenced by various parameters like size, shape or
composition. Comprehensive high throughput characterization techniques are urgently …

Influence of the polydispersity of pH 2 and pH 3.5 beta-lactoglobulin amyloid fibril solutions on analytical methods

TR Heyn, VM Garamus, HR Neumann… - European Polymer …, 2019 - Elsevier
It is well known that amyloid beta-lactoglobulin (BLG) fibril solutions contain a
heterogeneous mixture of amyloid aggregates and non-amyloid material. However, few …

Advanced multiwavelength detection in analytical ultracentrifugation

J Pearson, J Walter, W Peukert, H Cölfen - Analytical chemistry, 2018 - ACS Publications
This work highlights significant advancements in detector hardware and software for
multiwavelength analytical ultracentrifugation (MWL-AUC) experiments, demonstrating …

[HTML][HTML] Quantitative evaluation of nanoparticle classification by size-exclusion chromatography

S Süß, C Metzger, C Damm, D Segets, W Peukert - Powder technology, 2018 - Elsevier
Although few attempts for classification of nanoparticles (NPs) in labscale do exist, the
transfer to industrial applications is still challenging. One promising separation method …