Microbiota succession throughout life from the cradle to the grave

C Martino, AH Dilmore, ZM Burcham… - Nature Reviews …, 2022 - nature.com
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

The gut ileal mucosal virome is disturbed in patients with Crohn's disease and exacerbates intestinal inflammation in mice

Z Cao, D Fan, Y Sun, Z Huang, Y Li, R Su… - Nature …, 2024 - nature.com
Gut bacteriome dysbiosis is known to be implicated in the pathogenesis of inflammatory
bowel disease (IBD). Crohn's disease (CD) is an IBD subtype with extensive mucosal …

Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

N Karcher, E Nigro, M Punčochář, A Blanco-Míguez… - Genome biology, 2021 - Springer
Background Akkermansia muciniphila is a human gut microbe with a key role in the
physiology of the intestinal mucus layer and reported associations with decreased body …

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation

F Adiliaghdam, H Amatullah, S Digumarthi… - Science …, 2022 - science.org
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel
disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that …

Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial …

K Wortelboer, PA de Jonge, TPM Scheithauer… - Nature …, 2023 - nature.com
Bacteriophages (phages) are bacterial viruses that have been shown to shape microbial
communities. Previous studies have shown that faecal virome transplantation can decrease …

The human virome: viral metagenomics, relations with human diseases, and therapeutic applications

GH Bai, SC Lin, YH Hsu, SY Chen - Viruses, 2022 - mdpi.com
The human body is colonized by a wide range of microorganisms. The field of viromics has
expanded since the first reports on the detection of viruses via metagenomic sequencing in …

Gut virome in inflammatory bowel disease and beyond

HM Tun, Y Peng, L Massimino, ZY Sin, TL Parigi… - Gut, 2024 - gut.bmj.com
Objective The gut virome is a dense community of viruses inhabiting the gastrointestinal tract
and an integral part of the microbiota. The virome coexists with the other components of the …

Fecal virus-like particles are sufficient to reduce necrotizing enterocolitis

SM Offersen, X Mao, MR Spiegelhauer, F Larsen… - Gut …, 2024 - Taylor & Francis
Fecal filtrate transfer (FFT) is emerging as a safer alternative to traditional fecal microbiota
transplantation (FMT)–particularly in the context of necrotizing enterocolitis (NEC), a severe …

Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease

X Tian, S Li, C Wang, Y Zhang, X Feng, Q Yan, R Guo… - Microbiome, 2024 - Springer
Background The gut virome has been implicated in inflammatory bowel disease (IBD), yet a
full understanding of the gut virome in IBD patients, especially across diverse geographic …