Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

TV Pyrkov, K Avchaciov, AE Tarkhov… - Nature …, 2021 - nature.com
We investigated the dynamic properties of the organism state fluctuations along individual
aging trajectories in a large longitudinal database of CBC measurements from a consumer …

The potential for complex computational models of aging

S Farrell, G Stubbings, K Rockwood, A Mitnitski… - Mechanisms of Ageing …, 2021 - Elsevier
The gradual accumulation of damage and dysregulation during the aging of living
organisms can be quantified. Even so, the aging process is complex and has multiple …

Interpretable machine learning for high-dimensional trajectories of aging health

S Farrell, A Mitnitski, K Rockwood… - PLoS Computational …, 2022 - journals.plos.org
We have built a computational model for individual aging trajectories of health and survival,
which contains physical, functional, and biological variables, and is conditioned on …

Aging clocks, entropy, and the limits of age-reversal

AE Tarkhov, KA Denisov, PO Fedichev - BioRxiv, 2022 - biorxiv.org
We analyze aging signatures of DNA methylation and longitudinal electronic medical
records from the UK Biobank datasets and observe that aging is driven by a large number of …

Generating synthetic aging trajectories with a weighted network model using cross-sectional data

S Farrell, A Mitnitski, K Rockwood, A Rutenberg - Scientific Reports, 2020 - nature.com
We develop a computational model of human aging that generates individual health
trajectories with a set of observed health attributes. Our model consists of a network of …

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts ultimate limit of human lifespan

TV Pyrkov, K Avchaciov, AE Tarkhov, LI Menshikov… - bioRxiv, 2019 - biorxiv.org
We analyzed aging trajectories of complete blood counts (CBC) and their association with
the incidence of chronic diseases and death in cohorts of aging individuals registered in the …

AI for Longevity: Getting Past the Mechanical Turk Model Will Take Good Data

L Peshkin, D Kriukov - Artificial Intelligence for Healthy Longevity, 2023 - Springer
We examine the promise and progress of AI for healthy longevity, discuss the reasons for
success and failures, and anticipate the future. AI is about generalization—extrapolation …

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts ultimate human lifespan limit

T Pyrkov, K Avchaciov, A Tarkhov, L Menshikov… - 2020 - researchsquare.com
We investigated the dynamic properties of the organism state fluctuations along individual
aging trajectories in a large longitudinal database of CBC measurements from a consumer …

[HTML][HTML] Home/Nutriop Longevity Blog/What Is the Theoretical Upper Age Limit of Humans? Blood Cell Counts

YC is Empty - nutriop.com
Something is going to get you in the end—it could be cancer, diabetes, or a lightning strike.
But what if, in a perfect world, you were able to avoid all of those calamities, do away with …

[HTML][HTML] Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

OA Chagin - teletype.in
We investigated the dynamic properties of the organism state fluctuations along individual
aging trajectories in a large longitudinal database of CBC measurements from a consumer …