Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
Adipose organ development and remodeling
S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …
extension of obesity. Several observations converged on the idea that adipose tissues are …
Development of phenothiazine hybrids with potential medicinal interest: a review
The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …
Immunotherapy for cardiovascular disease
The outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study
(CANTOS) trial have unequivocally proven that inflammation is a key driver of …
(CANTOS) trial have unequivocally proven that inflammation is a key driver of …
Toward an understanding of how immune cells control brown and beige adipobiology
Immune cells were recently found to have an unexpected involvement in controlling the
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …
[HTML][HTML] The therapeutic potential of second and third generation CB1R antagonists
Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
Neurobiology of cannabinoid receptor signaling
B Lutz - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …
system. Despite its widespread localization, its functions within the context of distinct neural …
Reappraisal of Adipose Tissue Inflammation in Obesity
A Engin - Obesity and Lipotoxicity, 2024 - Springer
Chronic low-grade inflammation is a central component in the pathogenesis of obesity-
related expansion of adipose tissue and complications in other metabolic tissues. Five …
related expansion of adipose tissue and complications in other metabolic tissues. Five …
Monoacylglycerol lipase (MAGL) as a promising therapeutic target
A Gil-Ordóñez, M Martín-Fontecha… - Biochemical …, 2018 - Elsevier
Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …