Protein folding should be complex. Proteins organize themselves into specific three-
dimensional structures, through a myriad of conformational changes. The classical view of …

Protein folding has been viewed as a difficult problem of molecular self-organization. The
search problem involved in folding however has been simplified through the evolution of …

The associative memory, water mediated, structure and energy model (AWSEM) is a coarse-
grained protein force field. AWSEM contains physically motivated terms, such as hydrogen …

Compared with rapid accumulation of protein sequences from high-throughput DNA
sequencing, obtaining experimental 3D structures of proteins is still much more difficult …

Proteins have evolved to use water to help guide folding. A physically motivated,
nonpairwise-additive model of water-mediated interactions added to a protein structure …

Steady progress has been made in the field of ab initio protein folding. A variety of methods
now allow the prediction of low-resolution structures of small proteins or protein fragments …

Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides
and aligning to genome assemblies from related, modern species. Here, we report that skin …

The nucleosome is the fundamental unit for packaging the genome. A detailed molecular
picture for its conformational dynamics is crucial for understanding transcription and gene …

Energy–landscape theory has led to much progress in protein folding kinetics, protein
structure prediction and protein design. Funnel landscapes describe protein folding and …

The folding of proteins, the complex behavior of glasses, and the structure and dynamics of
atomic and molecular clusters have long been studied in separate disciplines. In recent …