Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

Rheumatoid arthritis (RA) is a chronic inflammatory synovitis that is dominated by the
presence of macrophages, lymphocytes and synovial fibroblasts, which leads to the …

Oncostatin M is a secreted cytokine involved in homeostasis and in diseases involving
chronic inflammation. It is a member of the gp130 family of cytokines that have pleiotropic …

Objective. The aim of this study was to investigate the effect of endogenous matrix
metalloproteinases 2 and 9 (MMP-2 and MMP-9) on the invasive characteristics of RA …

In common with many other cell types, synovial fibroblasts produce exosomes. In this study,
we show that the exosomes produced by synovial fibroblasts obtained from individuals with …

In addition to inhibiting persistent inflammation, phosphatase and tensin homolog deleted
from chromosome 10 (PTEN) is known as an important therapeutic target for alleviating …

Apoptosis is a key mechanism that regulates tissue composition and homeostasis.
Alterations in the apoptosis of synovial cells have been described in residential synoviocytes …

Expression of the chitinase 3-like protein HC-gp39 (human cartilage glycoprotein 39) is
associated with conditions of increased matrix turnover and tissue remodelling. High levels …