Two decades of Martini: Better beads, broader scope

SJ Marrink, L Monticelli, MN Melo… - Wiley …, 2023 - Wiley Online Library
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Lipid–protein interactions are unique fingerprints for membrane proteins

V Corradi, E Mendez-Villuendas, HI Ingólfsson… - ACS central …, 2018 - ACS Publications
Cell membranes contain hundreds of different proteins and lipids in an asymmetric
arrangement. Our current understanding of the detailed organization of cell membranes …

Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Multifaceted computational modeling in glycoscience

S Perez, O Makshakova - Chemical Reviews, 2022 - ACS Publications
Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Molecular dynamics simulations in photosynthesis

N Liguori, R Croce, SJ Marrink, S Thallmair - Photosynthesis research, 2020 - Springer
Photosynthesis is regulated by a dynamic interplay between proteins, enzymes, pigments,
lipids, and cofactors that takes place on a large spatio-temporal scale. Molecular dynamics …

Develo** and testing of lipid force fields with applications to modeling cellular membranes

AN Leonard, E Wang, V Monje-Galvan… - Chemical …, 2019 - ACS Publications
The amphipathic nature of the lipid molecule (hydrophilic head and hydrophobic tails)
enables it to act as a barrier between fluids with various properties and to sustain an …

Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class FG protein-coupled receptor smoothened

G Hedger, H Koldsø, M Chavent, C Siebold, R Rohatgi… - Structure, 2019 - cell.com
Transduction of Hedgehog signals across the plasma membrane is facilitated by the class F
G-protein-coupled-receptor (GPCR) Smoothened (SMO). Recent studies suggest that SMO …

Lipid dependence of xanthophyll cycling in higher plants and algae

R Goss, D Latowski - Frontiers in plant science, 2020 - frontiersin.org
The xanthophyll cycles of higher plants and algae represent an important photoprotection
mechanism. Two main xanthophyll cycles are known, the violaxanthin cycle of higher plants …