Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell‐mediated
autoimmune disease characterized by selective destruction of pancreatic β cells. The …

Autoimmune diabetes is a disease characterized by the selective destruction of insulin-
secreting β-cells of the endocrine pancreas by islet-reactive T cells. Autoimmune disease …

Introduction In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the
insulin B chain peptide 9-23 (B: 9-23) can bind to the MHC class II molecule (IAg7) in …

Certain class II MHC (MHCII) alleles in mice and humans confer risk for or protection from
type 1 diabetes (T1D). Insulin is a major autoantigen in T1D, but how its peptides are …

The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese
diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9 …

Insulin-specific CD4+ T cells are required for type 1 diabetes. How these cells are regulated
and how tolerance breaks down are poorly understood because of a lack of reagents …

The trimolecular complex composed of autoreactive T-cell receptor, MHC class II, and an
autoantigenic peptide plays a central role in the activation of pathogenic Islet-specific CD4+ …

Type 1A diabetes (autoimmune) is now immunologically predictable in man, but preventable
only in animal models. What triggers the development of autoimmunity in genetically …

The earliest events leading to autoimmune type 1 diabetes (T1D) are not known in any
species. A T-cell receptor (TCR)-variable region, TCR-Vβ13, is required for susceptibility to …

Activation of T cells specific for insulin B chain amino acids 9 to 23 (B: 9–23) is essential for
the initiation of type 1 diabetes (T1D) in non-obese diabetic mice. We previously reported …