The Kronos early estrogen prevention study (KEEPS): what have we learned?
Objective: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address
gaps in understanding the effects of timely menopausal hormone treatments (HT) on …
gaps in understanding the effects of timely menopausal hormone treatments (HT) on …
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
Background and Objectives White matter hyperintensities (WMHs) are frequent imaging
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …
Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a …
CR Jack, HJ Wiste, SD Weigand, TM Therneau… - The Lancet …, 2017 - thelancet.com
Background A new classification for biomarkers in Alzheimer's disease and cognitive ageing
research is based on grou** the markers into three categories: amyloid deposition (A) …
research is based on grou** the markers into three categories: amyloid deposition (A) …
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
The plasma proteomic changes that precede the onset of dementia could yield insights into
disease biology and highlight new biomarkers and avenues for intervention. We quantified …
disease biology and highlight new biomarkers and avenues for intervention. We quantified …
Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
P Vemuri, TG Lesnick, SA Przybelski, DS Knopman… - Brain, 2015 - academic.oup.com
Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …
[HTML][HTML] White-matter integrity on DTI and the pathologic staging of Alzheimer's disease
Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged
Alzheimer's disease (AD) patients (n= 46). Patients with antemortem DTI studies and a …
Alzheimer's disease (AD) patients (n= 46). Patients with antemortem DTI studies and a …
Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: atherosclerosis risk in communities-neurocognitive study
DS Knopman, ME Griswold, ST Lirette, RF Gottesman… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—The relationships between cerebrovascular lesions visible on
imaging and cognition are complex. We explored the possibility that the cerebral cortical …
imaging and cognition are complex. We explored the possibility that the cerebral cortical …
Characterization of white matter hyperintensities in large-scale MRI-studies
Background: White matter hyperintensities of presumed vascular origin (WMH) are a
common finding in elderly people and a growing social malady in the aging western …
common finding in elderly people and a growing social malady in the aging western …
Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes
Alzheimer's disease can present clinically with either the typical amnestic phenotype or with
atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy …
atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy …
Association of bilateral sal**o-oophorectomy before menopause onset with medial temporal lobe neurodegeneration
Importance There is an increased risk of cognitive impairment or dementia in women who
undergo bilateral sal**o-oophorectomy (BSO) before menopause. However, data are …
undergo bilateral sal**o-oophorectomy (BSO) before menopause. However, data are …