Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Immune checkpoint blockade (ICB) therapies have achieved clinical benefit, but most
'immune-cold'solid tumors are not responsive. The diversity of immune evasion mechanisms …

Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …